Gene

rho

ID

ZDB-GENE-990415-271

Name

rhodopsin

Symbol

rho Nomenclature History

Previous Names

Rh
opsin-like gene
rh1.1 (1)
rod opsin
wu:fi06d11 (1)
zfo2
zfrho

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Enables G protein-coupled photoreceptor activity and retinal binding activity. Acts upstream of or within absorption of visible light. Located in photoreceptor outer segment. Is expressed in several structures, including digestive system; endocrine system; photoreceptor cell; presumptive neural retina; and visual system. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 1; fundus albipunctatus; night blindness; retinitis pigmentosa; and retinitis pigmentosa 4. Orthologous to human RHO (rhodopsin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

157 figures from 108 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55266 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rho Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital stationary night blindness autosomal dominant 1	Alliance	Night blindness, congenital stationary, autosomal dominant 1	610445
fundus albipunctatus	Alliance	Retinitis punctata albescens	136880
retinitis pigmentosa 4	Alliance	Retinitis pigmentosa 4, autosomal dominant or recessive	613731

Associated With rho Via Experimental Models

Human Disease	Fish	Conditions	Citations
retinitis pigmentosa	rho^fl9/+	standard conditions	Zelinka et al., 2018
retinitis pigmentosa	rho^fl7/+	standard conditions	Zelinka et al., 2018
retinitis pigmentosa	rho^fl6/fl6	standard conditions	Zelinka et al., 2018
retinitis pigmentosa	rho^fl8/+	standard conditions	Zelinka et al., 2018
retinitis pigmentosa	rho^fl10/+	standard conditions	Zelinka et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR027430	Visual pigments (opsins) retinal binding site
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Domain	IPR019477	Rhodopsin, N-terminal
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR000732	Rhodopsin
Family	IPR001760	Opsin
Family	IPR050125	G-protein coupled receptor opsins

Domain Details Per Protein

Protein	Length	GPCR, rhodopsin-like, 7TM	G-protein coupled receptor opsins	G protein-coupled receptor, rhodopsin-like	Opsin	Rhodopsin	Rhodopsin, N-terminal	Visual pigments (opsins) retinal binding site
UniProtKB:P35359 InterPro	354

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	rho-201 (1) Ensembl	Ensembl		1,555 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab3-rho	monoclonal	rho	IgG1	Mouse	IHC	Sigma-Aldrich Santa Cruz Biotechnology, Inc. Millipore Abcam plc	49
Ab5-rho	monoclonal	exorh rho		Mouse	IHC WB	Millipore Abcam plc	48
Ab1-rho	monoclonal	rho		Mouse	IHC		34
Ab4-rho	monoclonal	rho		Mouse	IHC		5
Ab2-rho	polyclonal	rho		Rabbit	IHC		23
Ab10-rho	polyclonal	rho		Mouse	IHC WB	ABclonal	3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations