Gene

rho

ID

ZDB-GENE-990415-271

Name

rhodopsin

Symbol

rho Nomenclature History

Previous Names

Rh
opsin-like gene
rh1.1 (1)
rod opsin
wu:fi06d11 (1)
zfo2
zfrho

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Enables G protein-coupled photoreceptor activity and retinal binding activity. Involved in rhodopsin mediated signaling pathway. Acts upstream of or within absorption of visible light. Located in photoreceptor outer segment. Is expressed in several structures, including digestive system; endocrine system; photoreceptor cell; presumptive neural retina; and visual system. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 1; fundus albipunctatus; night blindness; retinitis pigmentosa; and retinitis pigmentosa 4. Orthologous to human RHO (rhodopsin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

146 figures from 99 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:55266 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rho Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital stationary night blindness autosomal dominant 1	Alliance	Night blindness, congenital stationary, autosomal dominant 1	610445
fundus albipunctatus	Alliance	Retinitis punctata albescens	136880
retinitis pigmentosa 4	Alliance	Retinitis pigmentosa 4, autosomal dominant or recessive	613731

Associated With rho Via Experimental Models

Human Disease	Fish	Conditions	Citations
retinitis pigmentosa	rho^fl9/+	standard conditions	Zelinka et al., 2018
retinitis pigmentosa	rho^fl7/+	standard conditions	Zelinka et al., 2018
retinitis pigmentosa	rho^fl6/fl6	standard conditions	Zelinka et al., 2018
retinitis pigmentosa	rho^fl8/+	standard conditions	Zelinka et al., 2018
retinitis pigmentosa	rho^fl10/+	standard conditions	Zelinka et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR027430	Visual pigments (opsins) retinal binding site
Domain	IPR017452	GPCR, rhodopsin-like, 7TM
Domain	IPR019477	Rhodopsin, N-terminal
Family	IPR000276	G protein-coupled receptor, rhodopsin-like
Family	IPR000732	Rhodopsin
Family	IPR001760	Opsin

Domain Details Per Protein

Protein	Length	GPCR, rhodopsin-like, 7TM	G protein-coupled receptor, rhodopsin-like	Opsin	Rhodopsin	Rhodopsin, N-terminal	Visual pigments (opsins) retinal binding site
UniProtKB:P35359 InterPro	354

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	rho-201 (1) Ensembl	1555 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab3-rho	monoclonal	rho	IgG1	Mouse	IHC	Sigma-Aldrich Santa Cruz Biotechnology, Inc. Millipore Abcam plc	41
Ab5-rho	monoclonal	exorh rho		Mouse	IHC WB	Millipore Abcam plc	41
Ab1-rho	monoclonal	rho		Mouse	IHC		33
Ab4-rho	monoclonal	rho		Mouse	IHC		5
Ab2-rho	polyclonal	rho		Rabbit	IHC		21
Ab10-rho	polyclonal	rho		Mouse	IHC WB	ABclonal	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations