ZFIN ID: ZDB-GENE-990415-271
Gene Name: rhodopsin
Gene Symbol: rho    Nomenclature History

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Previous Names: Rh, opsin-like gene, rh1.1 (1), rod opsin, wu:fi06d11 (1), zfo2, zfrho

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits G protein-coupled photoreceptor activity and retinal binding activity. Involved in absorption of visible light. Localizes to photoreceptor outer segment. Is expressed in several structures, including digestive system; endocrine system; photoreceptor cell; presumptive neural retina; and visual system. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 1; fundus albipunctatus; night blindness; retinitis pigmentosa; and retinitis pigmentosa 4. Orthologous to human RHO (rhodopsin).
Genome Resources: Alliance (1),  Gene:30295 (1),  Ensembl(GRCz11):ENSDARG00000002193 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
djh503 Small Deletion Unknown Frameshift CRISPR
fl6 Indel Exon 1 Premature Stop CRISPR
fl7 Indel Unknown Inframe Deletion CRISPR
fl8 Indel Unknown Inframe Deletion CRISPR
fl9 Small Deletion Unknown Premature Stop CRISPR
fl10 Small Deletion Unknown Inframe Deletion CRISPR
ouc2003 Small Deletion Unknown Premature Stop CRISPR
sa21401 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31692 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH rho HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital stationary night blindness autosomal dominant 1 Alliance Night blindness, congenital stationary, autosomal dominant 1 610445
    fundus albipunctatus Alliance Retinitis punctata albescens 136880
    retinitis pigmentosa 4 Alliance Retinitis pigmentosa 4, autosomal dominant or recessive 613731
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process absorption of visible light (more)
    Cellular Component photoreceptor outer segment (more)
    Molecular Function G protein-coupled photoreceptor activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rho-201 (1)    Ensembl 1555
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab3-rho monoclonal IgG1 Mouse IHC Sigma-Aldrich
    Santa Cruz Biotechnology, Inc.
    Millipore
    Abcam plc
    27
    Ab5-rho monoclonal Mouse IHC, WB Abcam plc
    27
    Ab1-rho monoclonal Mouse IHC 28
    Ab4-rho monoclonal Mouse IHC 5
    Ab2-rho polyclonal Rabbit IHC 20
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rho
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.1rho:EGFP) rho EGFP Danio rerio 1 5
    Tg(-3.7rho:EGFP) rho EGFP Danio rerio 1 22
    Tg(rho:1prpf31-mCherry) rho mCherryprpf31 Danio rerio 1 3
    Tg(rho:adcy2b) rho adcy2b Danio rerio 1 3
    Tg(rho:adcy2b-rho) rho adcy2brho Danio rerio 1 3
    Tg(rho:Eco.NfsB-EGFP) rho EGFP Danio rerioEscherichia coli 2 10
    Tg(rho:EGFP) rho EGFP Danio rerio 1 4
    Tg(rho:EGFP-Hsa.MAPT) rho EGFP Danio rerioHomo sapiens 1 5
    tg(rho:egfp-hsa.mapt_p301l) rho EGFP Danio rerioHomo sapiens 1 1
    Tg(rho:EGFP-HTTQ23) rho EGFP Danio rerio 1 3
    Tg(rho:EGFP-HTTQ71) rho EGFP Danio rerio 1 6
    Tg(rho:es1,rho:EGFP) rho EGFPes1 Danio rerio 1 1
    Tg(rho:grk1a) rho grk1a Danio rerio 2 2
    Tg(rho:grk7a) rho grk7a Danio rerio 3 2
    Tg(rho:Hsa.CETN2-EGFP) rho EGFP Danio rerioHomo sapiens 1 1
    Tg(rho:Hsa.RH1_Q344X) rho Danio rerioHomo sapiens 1 3
    tg(rho:hsa.ush2a-1) rho Danio rerioHomo sapiens 0 1
    tg(rho:hsa.ush2a-2) rho Danio rerioHomo sapiens 0 1
    tg(rho:mcherry-cracr2aa) rho cracr2aamCherry Danio rerio 1 1
    Tg(rho:mCherry-rab8a) rho mCherryrab8a Danio rerio 1 1
    Tg(rho:MITO-EGFP) rho EGFPMITO Danio rerio 1 1
    Tg(rho:ndrg1a-IRES-mSEGFP-CAAX) rho CAAXGFPIRESndrg1a Danio rerio 1 1
    Tg(rho:ndrg1b-IRES-mSEGFP-CAAX) rho CAAXGFPIRESndrg1b Danio rerio 1 1
    tg(rho:ntr-mcherry) rho mCherryNTR Danio rerio 1 1
    Tg(rho:prpf31-mCherry) rho mCherryprpf31 Danio rerio 1 3
    Tg(rho:SFtag-whrna) rho whrna Danio rerio 1 1
    Tg(rho:shGFP) rho shGFP Danio rerio 1 5
    Tg(rho:YFP-NTR) rho NTRYFP Danio rerio 1 5
    Tg1(rho-exorh:EGFP) exorhrho EGFP Danio rerio 1 4
    Tg2(rho-exorh:EGFP) exorhrho EGFP Danio rerio 1 3
    Tg2(rho:EGFP) rho EGFP Danio rerio 1 8
    Tg2(rho:ndrg1a-IRES-mSEGFP-CAAX) rho CAAXGFPIRESndrg1a Danio rerio 1 1
    Tg3(rho:EGFP) rho EGFP Danio rerio 1 4
    Tg4(rho:EGFP) rho EGFP Danio rerio 1 1
    Tg5(rho:EGFP) rho EGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    rho Contained in: [Fosmid] CH1073-268B21 (1), CH1073-274H22 (1)
    rho Contains: [SNP] rs3729490 (1)
    rho Encodes: [EST] fi06d11 (1)
    [cDNA] MGC:55266 (1), MGC:77587 (1), MGC:191346 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131084 (1) 1584 nt
    Genomic GenBank:CU638733 (1) 38253 nt
    Select Tool
    Polypeptide UniProtKB:B8JMK8 (1) 354 aa
    Sequence Information (all 43)
    ORTHOLOGY for rho ( Chr: 8 )
    CITATIONS (212)