ZFIN ID: ZDB-GENE-991229-12
Gene Name: extra-ocular rhodopsin
Gene Symbol: exorh    Nomenclature History

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Previous Names: Ex, exo-rod (1), ExoRh, ExR, exo-rhodopsin, zfExR (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Exhibits G protein-coupled photoreceptor activity and retinal binding activity. Involved in absorption of visible light and circadian regulation of gene expression. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 1; fundus albipunctatus; night blindness; retinitis pigmentosa; and retinitis pigmentosa 4. Is expressed in several structures, including digestive system; heart; nervous system; testis; and yolk. Orthologous to human RHO (rhodopsin).
Genome Resources: Alliance (1),  Gene:30459 (1),  Ensembl(GRCz11):ENSDARG00000111860 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-exorh N/A 2
MO2-exorh N/A 1
MO3-exorh N/A 1
DISEASE ASSOCIATED WITH exorh HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH exorh VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process absorption of visible light (more)
Cellular Component integral component of membrane (more)
Molecular Function G protein-coupled photoreceptor activity (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000732 Rhodopsin
Family IPR001760 Opsin
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Domain IPR019477 Rhodopsin, N-terminal
Binding_site IPR027430 Visual pigments (opsins) retinal binding site
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab5-rho monoclonal Mouse IHC, WB Abcam plc
26
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM exorh
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(exorh:EGFP) exorh EGFP Danio rerio 1 5
Tg1(rho-exorh:EGFP) exorhrho EGFP Danio rerio 1 4
Tg2(rho-exorh:EGFP) exorhrho EGFP Danio rerio 1 3
MARKER RELATIONSHIPS
exorh Encodes: [cDNA] MGC:109852 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131212 (1) 1982 bp
Genomic RefSeq:NW_003337228 (1) Blast at MegaBLAST
Polypeptide UniProtKB:Q9PTX9 (1) 354 aa
Sequence Information (all 15)
ORTHOLOGY for exorh ( Chr: 8 )
CITATIONS (35)