Gene

ctbp2a

ID

ZDB-GENE-010130-2

Name

C-terminal binding protein 2a

Symbol

ctbp2a Nomenclature History

Previous Names

CtBP2 (1)
ctbp2
fe05b01
riba
ribeye a (1)
wu:fb96g03 (1)
wu:fe05b01 (1)
wu:fk19e02

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable several functions, including transcription coactivator activity; transcription coregulator binding activity; and transcription corepressor activity. Acts upstream of or within several processes, including nervous system development; regulation of gliogenesis; and regulation of melanocyte differentiation. Predicted to be active in nucleus. Is expressed in nervous system; neural plate; otic vesicle; pectoral fin; and pharyngeal arch. Orthologous to human CTBP2 (C-terminal binding protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:77268 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctbp2a Human Ortholog

No data available

Associated With ctbp2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR029753	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
Domain	IPR006139	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Domain	IPR006140	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
Family	IPR043322	C-terminal binding protein
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily

Domain Details Per Protein

Protein	Length	C-terminal binding protein	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site	NAD(P)-binding domain superfamily
UniProtKB:F8W571 InterPro	313
UniProtKB:A9UL56 InterPro	710
UniProtKB:Q6NZ25 InterPro	404
UniProtKB:F8W4E9 InterPro	1156
UniProtKB:F8W438 InterPro	189
UniProtKB:F8W377 InterPro	165
UniProtKB:F8W3Q3 InterPro	150
UniProtKB:Q5BU18 InterPro	670
UniProtKB:Q7SZN5 InterPro	405
UniProtKB:F1RA12 InterPro	710
UniProtKB:Q5BU19 InterPro	1147
UniProtKB:F1QMW3 InterPro	1148
UniProtKB:A0A2R8QBA1 InterPro	1200
UniProtKB:A0A0R4IFH8 InterPro	1196
UniProtKB:Q7ZVY6 InterPro	404
UniProtKB:Q9DEG6 InterPro	444
UniProtKB:F8W3U1 InterPro	670
UniProtKB:F8W509 InterPro	251

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	ctbp2a-201 (1) Ensembl	3746 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctbp2a-203 (1) Ensembl	3035 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctbp2a-204 (1) Ensembl	3471 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctbp2a-205 (1) Ensembl	825 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctbp2a-206 (1) Ensembl	2013 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctbp2a-207 (1) Ensembl	2877 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctbp2a-208 (1) Ensembl	2605 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctbp2a-209 (1) Ensembl	1197 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctbp2a-210 (1) Ensembl	937 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctbp2a-211 (1) Ensembl	765 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctbp2a-212 (1) Ensembl	2375 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ctbp2a-213 (1) Ensembl	592 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
AB2-ctbp2a		ctbp2a		Chicken			1
Ab1-ctbp2a	polyclonal	ctbp2a		Rabbit	IHC		10

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations