FIGURE

Figure 8

ID

ZDB-FIG-260218-8

Publication

Dahlgren et al., 2026 - ER-associated degradation pathway protein SEL1L plays an evolutionarily conserved role in platelet adhesion

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Figure 8

Defective thrombocyte attachment in sel1l mutant zebrafish.

Laser-mediated arterial endothelial injury of a heterozygous incross at 5 dpf shows no difference in (A) time to first thrombocyte attachment (n = 15 +/+, 69 +/–, and 34 –/–) or (B) time to occlusion between WT (+/+), heterozygous (+/–), or homozygous (–/–) larvae (n = 25 +/+, 89 +/–, and 46 –/–), but there was a (C) significant decrease in the number of thrombocytes that attach to the site of injury in homozygous larvae compared with those that were WT and heterozygous (n = 15 +/+, 69 +/–, and 34 –/–). *P < 0.05 by Kruskal-Wallis test with multiple comparisons and an FDR correction.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sel1l^{mi4020/mi4020}; la2Tg (AB/TL)
Condition:	light ablation: blood vessel endothelium
Observed In:	blood vessel endothelium platelet aggregation blood vessel endothelium thrombocyte activation
Stage:	Day 5

Phenotype Detail

Acknowledgments

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