FIGURE

Figure 7

ID

ZDB-FIG-260218-7

Publication

Dahlgren et al., 2026 - ER-associated degradation pathway protein SEL1L plays an evolutionarily conserved role in platelet adhesion

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Figure 7

Altered TEG in Sel1l mutant mice.

TEG was performed on control Mx1-cre⁻Sel1l^fl/fl (n = 7) and knockdown Mx1-cre⁺ Sel1l^fl/fl (n = 6) mice. The results showed (A) no significant difference in reaction time, (B) a significant decrease in maximum amplitude, (C) a significant increase in the time for the clot to reach a strength of 20 mm (K time), (D) a significant decrease in the rate of clot formation (α-angle), and (E) a significant decrease in maximal rate of thrombus generation. (F) Representative tracings and velocity curves show the difference between the control in black and the KO in gray. *P < 0.05 and ***P < 0.001 by 2-tailed Student’s t test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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