FIGURE

Figure 6

ID

ZDB-FIG-260218-6

Publication

Dahlgren et al., 2026 - ER-associated degradation pathway protein SEL1L plays an evolutionarily conserved role in platelet adhesion

Other Figures

All Figure Page

Back to All Figure Page

Figure 6

Reduced adherence to collagen in Mx1-cre Sel1l^fl/fl platelets under flow.

(A) Representative images of murine platelets (green) adhering to a collagen-coated chamber after perfusion of whole blood from both a control Mx1-cre^–Sel1l^fl/fl and a knockdown Mx1-cre⁺ Sel1l^fl/fl mouse. Scale bars: 10 μm. (B) Quantification of the change in MFI between the beginning and end of the whole blood perfusion across collagen was normalized to the control for each pair. n = 6 cre⁺/cre^– sibling pairs. *P < 0.05 by Wilcoxon’s matched-pairs signed-rank test; a significant decrease in MFI change was found between control and knockdown groups.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Journal of Clin. Invest.