FIGURE

Fig. 8

ID

ZDB-FIG-251110-8

Publication

Yu et al., 2025 - LPS disrupts erythroid-myeloid balance in zebrafish via Jak2/Stat3-Hif1a signaling

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Fig. 8

Hypoxia induces a bias in erythroid-myeloid hematopoietic differentiation via the Jak2/Stat3-Hif1a axis. (A) Western blot and quantitative analysis of protein expression in K562 cells with different treatments (n = 3). (B) Western blot and quantitative analysis of protein expression in THP-1 cells with different treatments (n = 3). (C) WISH images and quantitative analysis of hif1a expression in zebrafish larvae under various conditions. (D) Images of Tg(gata1a:DsRed; lyz:EGFP) zebrafish larvae. Quantitative analysis of neutrophils and erythrocytes in the CHT. In C-D, n = replicates per group. ∗∗∗P < 0.001.

Expression Data

Genes:	DsRed hif1aa
Fish:	sd2Tg/sd2Tg AB
Conditions:	hypoxia chemical treatment by environment: ruxolitinib, hypoxia
Anatomical Terms:	caudal hematopoietic tissue caudal hematopoietic tissue nucleate erythrocyte
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sd2Tg/sd2Tg AB
Conditions:	hypoxia chemical treatment by environment: ruxolitinib, hypoxia
Observed In:	caudal hematopoietic tissue caudal hematopoietic tissue nucleate erythrocyte
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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