FIGURE

Fig. 6

ID

ZDB-FIG-251110-6

Publication

Yu et al., 2025 - LPS disrupts erythroid-myeloid balance in zebrafish via Jak2/Stat3-Hif1a signaling

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Fig. 6

Ruxolitinib and hif1a knockdown rescue LPS-induced inhibition of erythropoiesis in zebrafish larvae. (A) WISH for hif1a expression in zebrafish larvae following different treatments. (B) O-dianisidine staining of erythroid cells. (C) Fluorescence analysis of Tg(gata1a:DsRed) zebrafish. Dashed lines indicate the CHT region for quantification. n = replicates per group. ∗∗∗P < 0.001.

Expression Data

Genes:	DsRed hif1aa
Fish:	sd2Tg/sd2Tg AB
Conditions:	chemical treatment by injection: lipopolysaccharide chemical treatment by environment: ruxolitinib, chemical treatment by injection: lipopolysaccharide
Anatomical Terms:	caudal hematopoietic tissue caudal hematopoietic tissue nucleate erythrocyte
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sd2Tg/sd2Tg AB
Conditions:	chemical treatment by injection: lipopolysaccharide chemical treatment by environment: ruxolitinib, chemical treatment by injection: lipopolysaccharide
Observed In:	caudal hematopoietic tissue caudal hematopoietic tissue nucleate erythrocyte
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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