FIGURE

Figure 1

ID

ZDB-FIG-250826-31

Publication

Masiero et al., 2025 - Combined antiresorptive and new anabolic drug approach in osteogenesis imperfecta zebrafish models

Other Figures

All Figure Page

Back to All Figure Page

Figure 1

Bone geometrical parameters. (A) Representative 3-dimensional (3D) models of WT and untreated and treated Chi/+ fish. Scale bar: 100 μm. (B) Micro-CT (μCT) analysis of bone volume (BV), vertebral thickness (V.Th), and BMD in WT, Chi/+ (i), and Chi/+ untreated and treated with 4PBA, ALN, and 4PBA + ALN (ii). (C) Representative 3D models of WT and untreated and treated p3h1^−/− fish. Scale bar: 100 μm. (D) μCT analysis of BV, V.Th, and BMD in WT, p3h1^−/− (i), and p3h1^−/− untreated and treated with 4PBA, ALN, and 4PBA + ALN (ii). In the graphs, each dot represents a single value. ^*p < .05, ^**p < .01, ^*^*^*p < .001. Abbreviations: ALN, alendronate; 4PBA, 4-phenylbutyrate.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	p3h1^upv2/upv2 col1a1a^dc124/+
Condition:	chemical treatment by environment: alendronic acid
Observed In:	vertebra vertebra bone mineralization
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ JBMR Plus