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Publication: Masiero et al., 2025 - Combined antiresorptive and new anabolic drug approach in osteogenesis imperfecta zebrafish models
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Figure 1

Bone geometrical parameters. (A) Representative 3-dimensional (3D) models of WT and untreated and treated Chi/+ fish. Scale bar: 100 μm. (B) Micro-CT (μCT) analysis of bone volume (BV), vertebral thickness (V.Th), and BMD in WT, Chi/+ (i), and Chi/+ untreated and treated with 4PBA, ALN, and 4PBA + ALN (ii). (C) Representative 3D models of WT and untreated and treated p3h1^−/− fish. Scale bar: 100 μm. (D) μCT analysis of BV, V.Th, and BMD in WT, p3h1^−/− (i), and p3h1^−/− untreated and treated with 4PBA, ALN, and 4PBA + ALN (ii). In the graphs, each dot represents a single value. ^*p < .05, ^**p < .01, ^*^*^*p < .001. Abbreviations: ALN, alendronate; 4PBA, 4-phenylbutyrate.

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