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ZDB-FIG-250813-29

Publication

Zimmerman et al., 2025 - Investigating Psychopharmaceutical Effects on Early Vertebrate Development Using a Zebrafish Model System

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Fig. 1

Development of a zebrafish model system to examine the effects of psychopharmaceuticals on the cholesterol synthesis and early vertebrate development. (A) Summary of cholesterol synthesis pathways and proposed effects of psychopharmaceuticals. Products of the cholesterol biosynthesis pathways are shown in black. Enzymes of cholesterol biosynthesis pathways are shown in blue. AY9944 inhibits DHCR7 and is used as a positive control to demonstrate the effect of blocking DHCR7 and reducing desmosterol levels. Psychopharmaceuticals are hypothesized to inhibit DHCR7 in zebrafish and have similar effects to AY9944 on zebrafish development and behavior (indicated by ???). (B) Zebrafish model system for the evaluation of AY9944 and psychopharmaceuticals. Following treatment optimization, AY9944 and psychopharmaceuticals at 1 µM were administered at three days post fertilization (dpf) and 24 h prior to endogenous cholesterol synthesis. Following 48 h of exposure, 5dpf zebrafish were collected for multiple analyses.

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