FIGURE

Fig. 3

ID

ZDB-FIG-250609-102

Publication

Kuo et al., 2025 - The histamine pathway is a target to treat hepatic experimental erythropoietic protoporphyria

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Fig. 3

CCZ reduces tissue PP-IX levels and liver injury and protein oxidation in female but not male fch/fch mice. (A) PP-IX levels in the liver, erythrocytes, bone marrow, internal rectal stool, plasma, and bile. (B) Plasma ALT, ALP, and total bilirubin levels. (C) Cage stool was collected every 48 hours. Stool PP-IX levels were then measured. Total stool PP-IX level over the 10-day study period was calculated using the integrated area under the fluorescence curve. Data are shown as mean ± SD (n = 8–11 mice/group, N = 2 experiments). Statistical analysis was performed by ANOVA test, ∗P < .05. (D) Immunoblots of p62 monomer and its high molecular weight aggregates in 2% SDS-containing buffer. (E) Densitometry analysis of p62 monomer and high molecular weight aggregates. Statistical analysis was performed by 2-tailed Student t-test, ∗∗∗P < .001. (F) Oxyblots of total fch/fch or wild-type livers treated with the vehicle PBS or CCZ. CM, Coomassie staining.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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