FIGURE

Figure 5

ID

ZDB-FIG-250607-32

Publication

Chen et al., 2025 - KDM6A Deficiency Induces Myeloid Bias and Promotes CMML-Like Disease Through JAK/STAT3 Activation by Repressing SOCS3

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Figure 5

Haploinsufficiency of Kdm6a dysregulates aging related gene expression in HSPCs. A) Flowchart of sorting and RNA sequencing. B) Heatmap of differentially expressed genes in HSPCs from kdm6a^+/− mutants and their WT controls at 3 dpf via RNA‐seq (cut‐off fold change 1.5, p < 0.05). C) Gene ontology (GO) enrichment analysis of biological processes based on differentially expressed genes identified through RNA‐seq. D) Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis based on differentially expressed genes identified through RNA‐seq. E) Gene set enrichment analysis (GESA) of RNA expression profiles in HSPCs from kdm6a^+/− mutants and their WT controls at 3 dpf.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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