FIGURE

Fig. 9

ID

ZDB-FIG-250512-62

Publication

Fargher et al., 2025 - A zebrafish model of acmsd deficiency does not support a prominent role for ACMSD in Parkinson's disease

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Fig. 9

Kynurenine pathway metabolites were altered in acmsd^-/- adult tissues.

In adult liver tissue, kynurenine was reduced in acmsd^-/- zebrafish (A, p = 0.0079, Mann–Whitney test), no difference was identified between genotypes in kynurenic acid (B, p = 0.9125, unpaired, two-tailed t test) or 3-hydroxykynurenine (C, p = 0.0986, unpaired, two-tailed t test), whilst quinolinic acid was increased in acmsd^-/- (D, p = 0.0079, Mann–Whitney test). The kynurenic acid: kynurenine ratio (E, p = 0.0161, unpaired, two-tailed t test) and the 3-hydroxykynurenine:kynurenine ratio (F, p = 0.0063, unpaired, two-tailed t test) were increased in acmsd^-/- fish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	acmsd^sh619/sh619
Observed In:	liver 3-hydroxykynurenine liver kynurenic acid liver kynurenine liver quinolinic acid
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Parkinsons Dis