FIGURE

Fig. 5

ID

ZDB-FIG-250512-58

Publication

Fargher et al., 2025 - A zebrafish model of acmsd deficiency does not support a prominent role for ACMSD in Parkinson's disease

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Fig. 5

acmsd mutant zebrafish demonstrate normal swimming behaviour.

A Following habituation, 5dpf larvae were exposed to alternating dark (black bar)-light (white bar) cycles. B Total distance travelled was indistinguishable between genotypes (Kruskal-Wallis one-way ANOVA, p = 0.1902). n = 45 acmsd^-/-; 62 acmsd^+/-; 35 acmsd^+/+ from three biological replicates. C Following a habituation period, adult movement was recorded over 6 h at 9mpf. D. No difference in the total distance travelled was found between genotypes (unpaired two-tailed t test, p = 0.1796). n = 10 acmsd^-/-; 10 acmsd^+/+ (equal male/female ratio) taken at two separate time points. Graphs A + C show mean ± SEM. Graphs B + D show individual fish with mean ± SEM values.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	acmsd^sh619/sh619
Observed In:	response to light stimulus swimming behavior
Stage Range:	Day 5 to Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ NPJ Parkinsons Dis