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Fig. 9

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Publication: Fargher et al., 2025 - A zebrafish model of acmsd deficiency does not support a prominent role for ACMSD in Parkinson's disease
All Figures: Figures for Fargher et al., 2025

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Fig. 9 Kynurenine pathway metabolites were altered in acmsd^-/- adult tissues.

In adult liver tissue, kynurenine was reduced in acmsd^-/- zebrafish (A, p = 0.0079, Mann–Whitney test), no difference was identified between genotypes in kynurenic acid (B, p = 0.9125, unpaired, two-tailed t test) or 3-hydroxykynurenine (C, p = 0.0986, unpaired, two-tailed t test), whilst quinolinic acid was increased in acmsd^-/- (D, p = 0.0079, Mann–Whitney test). The kynurenic acid: kynurenine ratio (E, p = 0.0161, unpaired, two-tailed t test) and the 3-hydroxykynurenine:kynurenine ratio (F, p = 0.0063, unpaired, two-tailed t test) were increased in acmsd^-/- fish.

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