FIGURE

Fig. 8

ID

ZDB-FIG-250507-43

Publication

Shanbhag et al., 2025 - Pannexin-2 deficiency disrupts visual pathways and leads to ocular defects in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

Panx2 loss leads to lens malformation and decreased retinal thickness in adult zebrafish. Eyes of adult fish were imaged using a SD-OCT system. a) Schematic definition of four geometric parameters used for quantification of high-resolution OCT Whole-eye images. Representative images of Panx2+/+ (b) and Panx2Δ11 (c,d), showing disruptions in lens epithelium. Scale bars = 500 μm. Bar plots showing spread of quantified geometric parameters for the axial length normalized to body length (e), relative refractive error (f), corneal thickness normalized to lens diameter (h), and retinal thickness normalized to lens diameter (h) collectively showing significant differences between the genotypes. Sample sizes for Panx2+/+ and Panx2Δ11 were 38 and 40 eyes from 19 and 20 fish, respectively. Significance: ***P-value <0.001 and ****P-value <0.0001. See also Supplementary Table 7.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Biochimica et biophysica acta. Molecular basis of disease, , Shanbhag, R., Zoidl, G.S.O., Nakhuda, F., Sabour, S., Nauman, H., Zoidl, C., Bahl, A., Tabatabaei, N., Zoidl, G.R., Pannexin-2 deficiency disrupts visual pathways and leads to ocular defects in zebrafish, 167807167807, Copyright (2025) with permission from Elsevier. Full text @ BBA Molecular Basis of Disease