FIGURE

Fig. 2

ID

ZDB-FIG-250423-9

Publication

Lin et al., 2025 - Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade

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Fig. 2

TO network pharmacological results and validation. (A) MT-target network show the active ingredients of MT screened using TCMSP and predicted targets. (B) Venn diagram show the overlap of 114 targets genes of pharmacologically active compounds and liver toxicity relative genes. (C) GO and KEGG enrichment bubble plots. (D) PPI network diagrams of active ingredients and core targets of drugs. (E) Heatmap of the scores of key targets and active compounds of drugs. (F) Visualization of the docking results of the molecular interaction between TO and mTOR.

Expression Data

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Acknowledgments

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Reprinted from Phytomedicine : international journal of phytotherapy and phytopharmacology, 140, Lin, Y., Zhang, J., Gao, X., Wu, Z., Yang, L., Tian, K., Lv, X., Li, J., Chen, K., Zhang, Y., Hu, H., Zhu, A., Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade, 156586156586, Copyright (2025) with permission from Elsevier. Full text @ Phytomedicine