FIGURE

Fig. 8

ID

ZDB-FIG-250327-46

Publication

Berlingerio et al., 2025 - Targeting oxidative stress-induced lipid peroxidation enhances podocyte function in cystinosis

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Fig. 8

Combinatorial treatment with cysteamine and MitoTEMPO or liproxstatin-1 decreases 4-HNE protein expression in cystinosis podocytes. (a, b) Left panel: Representative western blot image of 4-hydroxynonenal (4-HNE)-conjugated protein levels in a. CTNS?/?#1 and b. CTNS?/?#2 treated with 100 �M cysteamine, 10 �M MitoTEMPO, 100 �M cysteamine?+?10 �M MitoTEMPO, 10 �M liproxstatin-1, or 100 �M cysteamine?+?10 �M liproxstatin-1 for 48 h. ?-Actin was used as a loading control. Right panel: Quantification of 4-HNE protein expression normalized to ?-Actin. (n?=?4 biological experiments, n?=?1 technical replicate) Statistical analysis: one-sample t-test, with WT set as the reference. AU?=?arbitrary units. Each dot represents a biological experiment

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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