FIGURE

Fig. 2

ID

ZDB-FIG-250327-40

Publication

Berlingerio et al., 2025 - Targeting oxidative stress-induced lipid peroxidation enhances podocyte function in cystinosis

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Cystinosis podocytes reveal decreased respiratory activity. Seahorse assay. (a, b) Upper panel: Oxygen consumption rate (OCR) in a. WT, CTNS−/−#1, and CTNS−/−#2, and b. shCTR, shCTNS#1, and shCTNS#2 at baseline and following injection of oligomycin, FCCP, and rotenone/antimycin A (R/A). Final concentrations: oligomycin (1.5 μM), FCCP (2 μM), rotenone (1.25 μM) and antimycin A (2.5 μM). Lower panel: quantification of basal respiration, maximal respiration, ATP production, and spare respiratory capacity in a. WT, CTNS−/−#1, and CTNS−/−#2, and b. shCTR, shCTNS#1, and shCTNS#2 (n = 4 biological experiments, n = 10 technical replicates). Statistical analysis: Dunnett’s one-way ANOVA. For each experiment, values were normalized to protein levels. Each dot represents a biological experiment

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Transl Med