FIGURE

Figure 2

ID

ZDB-FIG-250320-14

Publication

Manickam et al., 2025 - Paving the way for better ototoxicity assessments in cisplatin therapy using more reliable animal models

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Figure 2

Clinical cisplatin affects hearing function in mice in a dose-dependent manner. Eight weeks old mice (>20 grams) received clinical cisplatin in a multi-cycle protocol. Hearing function was measured before and after the completion of cisplatin treatment. The following groups were tested: age-matched controls (black circles), vehicle (saline solution, white circles), clinical cisplatin at 2 mg/kg b.w. (pink circles), 2.5 mg/kg b.w (red circles) and 3 mg/kg b.w. (marron circles). (A) ABR thresholds. (B) ABR threshold shifts. (C) DPOAEs thresholds. (D) DP amplitudes. Noise floor gray circles. Results are expressed as Mean +/– SD. Statistical analysis: Two-way ANOVA followed by Dunnett post-test for multiple comparisons. *p < 0.05, **p < 0.01, and ***p < 0.001 vehicle versus the corresponding color-coded treatment. Number of animals per group is between brackets.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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