FIGURE

Figure 3

ID
ZDB-FIG-250320-15
Publication
Manickam et al., 2025 - Paving the way for better ototoxicity assessments in cisplatin therapy using more reliable animal models
Other Figures
All Figure Page
Back to All Figure Page
Figure 3

Clinical cisplatin treatment results in hair cell damage. (A–L) Representative micrographs of the organ of Corti at three frequency regions (16 kHz, 32 kHz and 45 kHz). Hair cells were immunostained for myosin-7a (gray). (A–C) Vehicle. (D–F) Clinical cisplatin 2 mg/kg b.w. (G–I) 2.5 mg/kg b.w. (J–L) 3 mg/kg b.w. Scale bar = 10 μm. (M–O) OHC quantification at 16 kHz (M), 32 kHz (N) and 45 kHz (O) regions. Mean +/− SD. Circles represent individual animals. Statistical analysis: One-way ANOVA followed by Dunnett post-test for multiple comparisons. **p < 0.01, ***p < 0.001 versus vehicle. ns, not significant.

Expression Data

Expression Detail
Antibody Labeling
Phenotype Data

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.