FIGURE

Figure 3

ID

ZDB-FIG-250320-15

Publication

Manickam et al., 2025 - Paving the way for better ototoxicity assessments in cisplatin therapy using more reliable animal models

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Figure 3

Clinical cisplatin treatment results in hair cell damage. (A–L) Representative micrographs of the organ of Corti at three frequency regions (16 kHz, 32 kHz and 45 kHz). Hair cells were immunostained for myosin-7a (gray). (A–C) Vehicle. (D–F) Clinical cisplatin 2 mg/kg b.w. (G–I) 2.5 mg/kg b.w. (J–L) 3 mg/kg b.w. Scale bar = 10 μm. (M–O) OHC quantification at 16 kHz (M), 32 kHz (N) and 45 kHz (O) regions. Mean +/− SD. Circles represent individual animals. Statistical analysis: One-way ANOVA followed by Dunnett post-test for multiple comparisons. **p < 0.01, ***p < 0.001 versus vehicle. ns, not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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