FIGURE

Figure 6

ID

ZDB-FIG-250320-18

Publication

Manickam et al., 2025 - Paving the way for better ototoxicity assessments in cisplatin therapy using more reliable animal models

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Figure 6

Dose–response curve of clinical cisplatin in zebrafish. (A) Quantitative data obtained from 5 to 6 dpf zebrafish treated with vehicle (saline solution) or increasing concentrations of clinical cisplatin (100 μM to 600 μM) for 6 h. Results are expressed as number of hair cells per neuromast. Mean +/− SD. Circles represent individual animals. Statistical analysis: One-way ANOVA followed by Dunnett post-test for multiple comparisons. **p < 0.01, ***p < 0.001 versus vehicle. (B,C) Representative images of a neuromast from a fish treated with vehicle (B) or clinical cisplatin at the EC₅₀ (C, 400 μM). Hair cells were immunostained for otoferlin (red). Scale bar = 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment by environment: cisplatin
Observed In:	neuromast hair cell
Stage Range:	Day 5 to Day 6

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front. Cell. Neurosci.