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Figure 2
Clinical cisplatin affects hearing function in mice in a dose-dependent manner. Eight weeks old mice (>20 grams) received clinical cisplatin in a multi-cycle protocol. Hearing function was measured before and after the completion of cisplatin treatment. The following groups were tested: age-matched controls (black circles), vehicle (saline solution, white circles), clinical cisplatin at 2 mg/kg b.w. (pink circles), 2.5 mg/kg b.w (red circles) and 3 mg/kg b.w. (marron circles).