FIGURE

Figure 4

ID

ZDB-FIG-250320-16

Publication

Manickam et al., 2025 - Paving the way for better ototoxicity assessments in cisplatin therapy using more reliable animal models

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Figure 4

Clinical cisplatin treatment results in pre-synaptic ribbon loss at higher frequencies. (A–H) Representative micrographs of the organ of Corti at two frequency regions (32 kHz and 45 kHz). Pre-synaptic ribbons were immunostained for CtBP2 (red). Hair cells were delineated with white traces. (A,B) Vehicle. (C,D) Clinical cisplatin 2 mg/kg b.w. (E,F) 2.5 mg/kg b.w. (G,H) 3 mg/kg b.w. Scale bar = 10 μm. (I,J) pre-synaptic ribbon quantification at 32 kHz (I) and 45 kHz (J) regions. Mean +/− SD. Circles represent individual animals. Statistical analysis: One-way ANOVA followed by Dunnett post-test for multiple comparisons. **p < 0.01, ***p < 0.001 versus vehicle. ns, not significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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