FIGURE

Fig. 5

ID

ZDB-FIG-250304-5

Publication

Chen et al., 2025 - NDUFB7 mutations cause brain neuronal defects, lactic acidosis, and mitochondrial dysfunction in humans and zebrafish

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Fig. 5

Knockdown of Ndufb7 reduces the neuronal volume of the brain.

Transgenic Tg(Huc:kaede) zebrafish embryos were treated as described in Fig. 3, cultured until 48 hours post-fertilization, observed using a 10X objective, and photographed under a black field using a GFP cube under confocal microscopy. A All images are presented in lateral view. B The midbrain (mb) and hindbrain (hb) are pseudocolored in yellow and white, subjected to volume measurement using the Metamorph software, as shown in C midbrain and D hindbrain. The volume of each brain compartment was measured in voxels. Data from three independent experiments are presented, analyzed, and shown as described in Fig. 3. NS not significant; **p < 0.01; ***p < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	rw0130aTg + MO1-ndufb7
Condition:	chemical treatment by injection: Mitoquinone
Knockdown Reagent:	MO1-ndufb7
Observed In:	hindbrain neuron midbrain neuron
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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