FIGURE

Fig. 2

ID

ZDB-FIG-250304-2

Publication

Chen et al., 2025 - NDUFB7 mutations cause brain neuronal defects, lactic acidosis, and mitochondrial dysfunction in humans and zebrafish

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Fig. 2

Mitochondrial complex formation is disrupted in fibroblasts derived from the patient carrying the NDUFB7 mutations.

Using blue native polyacrylamide gel electrophoresis (BN-PAGE), mitochondrial extracts from control (C) and patient (P) skin fibroblasts were separated using Triton A X-100 or B digitonin. These extracts were probed for the indicated protein in parentheses to identify Complexes I–IV. Complex II served as a loading control, as shown at the bottom of each well, except in the Complex II lane. C The samples were further separated by 2D-SDS PAGE and probed for the indicated mitochondrial accessory proteins.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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