FIGURE

Figure 9.

ID

ZDB-FIG-250214-31

Publication

Wawruszak et al., 2025 - Selisistat, a SIRT1 inhibitor, enhances paclitaxel activity in luminal and triple-negative breast cancer: in silico, in vitro, and in vivo studies

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Figure 9.

Evaluation of single or combined drug-mediated effects on the induction of apoptosis in T47D BC cells. (a) The % of cells with active caspase-3 determined after PAX and EX527 treatment for 48 h using selected ratios of the IC₅₀ determined in the MTT assay. Data are presented as mean ± standard deviation (± SD) of the mean, *** p < 0.001 by one-way ANOVA, Tukey’s post-hoc test. (b) Representative dot plots from the FACS analysis of the T47D luminal-type BC cells after a 48h incubation with a medium PAX, EX527 or PAX:EX527 (1:1). R3-apoptotic cells with active caspase-3. (c) BAX relative gene expression in zebrafish T47D injected xenograft model after 72 h with 1/8 IC₅₀ EX527 or/and PAX treatment determined in qPCR method. *** p < 0.001 determined by one-way ANOVA, Tukey’s post-hoc test. (d) p21 relative expression in zebrafish T47D injected xenograft model after 72 h with 1/8 IC₅₀ EX527 or/and PAX treatment determined in qPCR method. *** p < 0.001 determined by one-way ANOVA, Tukey’s post-hoc test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Enzyme Inhib Med Chem