FIGURE

Figure 6.

ID

ZDB-FIG-250214-28

Publication

Wawruszak et al., 2025 - Selisistat, a SIRT1 inhibitor, enhances paclitaxel activity in luminal and triple-negative breast cancer: in silico, in vitro, and in vivo studies

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Figure 6.

In vivo experiments with zebrafish xenografted model. (a) Drug screening scheme with zebrafish larvae model. (b) The impact of 1/8 IC₅₀ EX527, PAX and the combination of both compounds (1/8 IC_{50 mix}) on T47D xenografted zebrafish model after 3 days of treatment. The representative images of Vybrant^™ DiD-stained tumour cells after treatment were illustrated. (c) Relative expression of human GAPDH versus zebrafish gapdh in zebrafish larvae after 1/8 IC₅₀ EX527, PAX and EX527:PAX (1/8 IC_{50 mix}) treatment. Data are presented as mean ± standard deviation of the mean (SD), ***p < 0.001 determined by one-way ANOVA, Tukey’s post-hoc test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Enzyme Inhib Med Chem