FIGURE

Figure 7.

ID

ZDB-FIG-250214-29

Publication

Wawruszak et al., 2025 - Selisistat, a SIRT1 inhibitor, enhances paclitaxel activity in luminal and triple-negative breast cancer: in silico, in vitro, and in vivo studies

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Figure 7.

Schematic representation of molecular interaction pathways between (a) SIRT1 or (b) SIRT3 with tubulin, as indicated by SIGNOR. The diagram showcases the proteins and molecules involved in the interaction network between molecular targets of EX527 and PAX. Different shapes and colours denote the nature of the entities, as explained in the legend panel. (c) The effects of PAX, SIRT and PAX:SIRT (1/8 IC₅₀ or 1/8 IC_{50 mix}) on the gene expressions in zebrafish xenografted BT-549 TNBC in vivo model after 72 treatment and analysed by the qRT-PCR. *p < 0.05, **p < 0.01 by one-way ANOVA, Tukey’s post-hoc test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Enzyme Inhib Med Chem