ZFIN Image: Wawruszak et al., 2025, Figure 7.

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Figure Caption

Figure 7.

Schematic representation of molecular interaction pathways between (a) SIRT1 or (b) SIRT3 with tubulin, as indicated by SIGNOR. The diagram showcases the proteins and molecules involved in the interaction network between molecular targets of EX527 and PAX. Different shapes and colours denote the nature of the entities, as explained in the legend panel. (c) The effects of PAX, SIRT and PAX:SIRT (1/8 IC₅₀ or 1/8 IC_{50 mix}) on the gene expressions in zebrafish xenografted BT-549 TNBC in vivo model after 72 treatment and analysed by the qRT-PCR. *p < 0.05, **p < 0.01 by one-way ANOVA, Tukey’s post-hoc test.

Acknowledgments

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