FIGURE

Figure 5

ID

ZDB-FIG-241019-54

Publication

Wijerathna et al., 2024 - CRISPR/Cas9-Mediated fech Knockout Zebrafish: Unraveling the Pathogenesis of Erythropoietic Protoporphyria and Facilitating Drug Screening

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Figure 5

Reduction in PPIX accumulation in fech^−/− larvae following UDCA treatment. WT and fech^−/− larvae (3 dpf) were treated with 100 or 200 µM of UDCA, and their PPIX fluorescence intensity was compared with that of untreated WT and fech^−/− larvae. (A) Fluorescence and bright-field images of WT and fech^−/− larvae after UDCA treatment as well as the controls. (B) The relative fluorescence intensities of PPIX in the experimental larvae. The relative fluorescence intensity data are presented as the means ± SD (n = 5). The statistical significance between control and treated larvae was analyzed using the Student’s t-test (ns, non-significant; **, p ≤ 0.01; ***, p ≤ 0.001; ****, p ≤ 0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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