FIGURE

Figure 12

ID

ZDB-FIG-241019-61

Publication

Wijerathna et al., 2024 - CRISPR/Cas9-Mediated fech Knockout Zebrafish: Unraveling the Pathogenesis of Erythropoietic Protoporphyria and Facilitating Drug Screening

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Figure 12

Attenuation of macrophage accumulation by UDCA treatment in fech^−/− larvae. (A) Images of neutral, red-stained macrophages in WT and fech^−/− larvae. (B) The total macrophage counts in WT and fech^−/− larvae. WT and fech^−/− larvae (3 dpf) were treated with 100 µM of UDCA, and another group was treated with DMSO for 24 h; the control group remained untreated. The total macrophage counts are presented as the means ± SD (n = 5). Statistical significance between the control, DMSO-treated, and UDCA-treated fech^−/− larvae was analyzed using Student’s t-test (ns, non-significant; ****, p ≤ 0.0001).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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