FIGURE

Fig. 2

ID

ZDB-FIG-240620-45

Publication

Gauthier et al., 2024 - Therapeutic antibody engineering for efficient targeted degradation of membrane proteins in lysosomes

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Fig. 2

Binding affinity of CTX-AMFA and TRZ-AMFA for M6PR and their target. (A) Binding affinity for M6PR. The affinity of CTX or CTX-AMFA (left) and TRZ or TRZ-AMFA (right) for M6PR was determined by ELISA. Results are presented as the absorbance of mAb or mAb-AMFA bound to M6PR and detected with HRP-conjugated anti-human IgG antibody. Non-specific adsorption values of the antibodies bound to uncoated wells are subtracted. (B) Antigen affinity. The affinity of CTX or CTX-AMFA (left) and TRZ or TRZ-AMFA (right) for EGFR and HER2, respectively, was determined by ELISA. Results are presented as the absorbance of mAb or mAb-AMFA detected by HRP-conjugated anti-human IgG antibody (mean � SEM from triplicates).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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