FIGURE

Figure 8

ID

ZDB-FIG-240606-44

Publication

Pan et al., 2024 - Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish

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Figure 8

Ingenuity Pathway Analysis (IPA) network pathway analysis uncovers dysregulated genes in LMNA mutant transgenic fish. (A) F2 LMNA(L35P) mutants exhibit dysregulation in genes associated with behavior deficits, movement disorders, and cycling of the centrosome. (B) Dysregulation of genes related to movement disorders is observed in F2 LMNA(R453W) mutants. (C) LMNA(A539V) mutants demonstrate dysregulation in genes associated with myocardial dysfunction. These findings obtained through IPA provide insights into the dysregulated pathways and potential molecular mechanisms underlying the observed phenotypic changes in LMNA mutant transgenic fish.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nn1022Tg/nn1022Tg nn1024Tg/nn1024Tg nn1026Tg/nn1026Tg
Observed In:	centrosome cycle cerebral blood circulation locomotory behavior myocardium
Stage:	Adult

Phenotype Detail

Acknowledgments

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