FIGURE

Figure 5

ID

ZDB-FIG-240606-41

Publication

Pan et al., 2024 - Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish

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Figure 5

The effects of chemical treatment on F2 heterozygous larvae of LMNA transgenic zebrafish. The larvae fish were subjected to chemical treatment, and their swim speed was assessed using DanioVision from 5 to 8 dpf. (A) l-carnitine 10 μM, (B) Creatine 100 μM, (C) Terazosin 2.5 μM, (D) Taurine 1 mM, (E) Tyrosine 10 μM treatments were administered to AB(WT), LMNA (WT), LMNA(A539V), LMNA(L35P), LMNA(R453W) larvae fish. Statistical analysis was conducted using a One-way ANOVA with Dunnett’s test comparing the swim speed of the chemically treated larvae to those with no drug treatment. Each dot represents one fish. AB(WT), LMNA(WT), LMNA(L35P), LMNA(E358K), LMNA(R453W), LMNA(A539V), n = 8 for each group. The presented P-values have been appropriately adjusted, and the level of statistical significance is expressed as a P-value, where indicated as following: *represents 0.01 < P ≤ 0.05, **represents 0.001 < P ≤ 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nn1022Tg/nn1022Tg nn1024Tg/nn1024Tg nn1026Tg/nn1026Tg
Conditions:	chemical treatment by environment: creatine chemical treatment by environment: carnitine chemical treatment by environment: taurine chemical treatment by environment: terazosin
Observed In:	locomotory behavior
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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