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Figure 8

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Publication: Pan et al., 2024 - Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish
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Figure 8

Ingenuity Pathway Analysis (IPA) network pathway analysis uncovers dysregulated genes in LMNA mutant transgenic fish. (A) F2 LMNA(L35P) mutants exhibit dysregulation in genes associated with behavior deficits, movement disorders, and cycling of the centrosome. (B) Dysregulation of genes related to movement disorders is observed in F2 LMNA(R453W) mutants. (C) LMNA(A539V) mutants demonstrate dysregulation in genes associated with myocardial dysfunction. These findings obtained through IPA provide insights into the dysregulated pathways and potential molecular mechanisms underlying the observed phenotypic changes in LMNA mutant transgenic fish.

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