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Figure 5

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Publication: Pan et al., 2024 - Creatine and L-carnitine attenuate muscular laminopathy in the LMNA mutation transgenic zebrafish
All Figures: Figures for Pan et al., 2024

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Figure 5

The effects of chemical treatment on F2 heterozygous larvae of LMNA transgenic zebrafish. The larvae fish were subjected to chemical treatment, and their swim speed was assessed using DanioVision from 5 to 8 dpf. (A) l-carnitine 10 μM, (B) Creatine 100 μM, (C) Terazosin 2.5 μM, (D) Taurine 1 mM, (E) Tyrosine 10 μM treatments were administered to AB(WT), LMNA (WT), LMNA(A539V), LMNA(L35P), LMNA(R453W) larvae fish. Statistical analysis was conducted using a One-way ANOVA with Dunnett’s test comparing the swim speed of the chemically treated larvae to those with no drug treatment. Each dot represents one fish. AB(WT), LMNA(WT), LMNA(L35P), LMNA(E358K), LMNA(R453W), LMNA(A539V), n = 8 for each group. The presented P-values have been appropriately adjusted, and the level of statistical significance is expressed as a P-value, where indicated as following: *represents 0.01 < P ≤ 0.05, **represents 0.001 < P ≤ 0.01.

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