FIGURE
Figure 8
- ID
- ZDB-FIG-240429-96
- Publication
- Jiang et al., 2024 - A Mechanistic Study of the Osteogenic Effect of Arecoline in an Osteoporosis Model: Inhibition of Iron Overload-Induced Osteogenesis by Promoting Heme Oxygenase-1 Expression
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Figure 8
Schematic illustration of ACL for protecting FAC induced osteoporosis via upregulation of HO-1. FAC treatment leads to increased intracellular iron levels, lipid peroxidation, mitochondrial dysfunction, and oxidative stress, contributing to the inhibition of osteoblast differentiation and progression of osteoporosis. ACL attenuates these inhibitory effects by upregulating HO-1 expression. HO-1 activation promotes iron recycling and exerts antioxidant effects, thereby suppressing hallmarks of ferroptosis. The illustration figure was created by BioRender. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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Full text @ Antioxidants (Basel)