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Figure 8
Schematic illustration of ACL for protecting FAC induced osteoporosis via upregulation of HO-1. FAC treatment leads to increased intracellular iron levels, lipid peroxidation, mitochondrial dysfunction, and oxidative stress, contributing to the inhibition of osteoblast differentiation and progression of osteoporosis. ACL attenuates these inhibitory effects by upregulating HO-1 expression. HO-1 activation promotes iron recycling and exerts antioxidant effects, thereby suppressing hallmarks of ferroptosis. The illustration figure was created by BioRender.
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Full text @ Antioxidants (Basel)