FIGURE

Figure 5

ID

ZDB-FIG-240327-25

Publication

Daurat et al., 2024 - Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins

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Figure 5

In vivo efficacy of BVZ-AMFA2_(n=5) in zebrafish angiogenesis model. Tg(fli1:eGFP) zebrafish embryos were injected intravenously with 15 ng BVZ or BVZ-AMFA2_(n=5) at 48 hours post fertilization. Zebrafish embryos were observed at 0, 24 and 48 h post-injection under confocal microscope. The representative fluorescence images of control (n=8) and embryos treated with BVZ (n=11) or BVZ-AMFA2_(n=5) (n=11) at 48 h post-injection are presented for the subintestinal vessels (SIVs) area, and the blood vessels are indicated by arrows (A). The SIVs area (B) and the number of blood vessels (C) were determined, and the results are expressed as the angiogenesis rate compared to the value at T0 or as the number of blood vessels, respectively. Tukey’s test: * p value < 0.05; ** p value < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Immunol