FIGURE

Fig. 5

ID

ZDB-FIG-240229-187

Publication

Bin et al., 2024 - Importin 13-dependent axon diameter growth regulates conduction speeds along myelinated CNS axons

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Fig. 5

Disruption of importin 13b function increases neurofilament density in the Mauthner axon.

A, B Representative electron micrographs of a cross-section of the Mauthner axon in the ventral spinal cord at 7 dpf in control and ipo13b^ue57zebrafish. A region of each axon is magnified in (C) (control) and (D) (ipo13b^ue57) to allow visualisation of the distribution of neurofilaments. E Density of neurofilaments in control and ipo13b^ue57 mutant Mauthner axons at 7 dpf (two-tailed unpaired t-test, n = 11 control and 8 ipo13b^ue57 animals, p = 0.0007). F Nearest neighbour distribution of neurofilaments in the Mauthner axon at 7 dpf, showing a shift to closer nearest neighbours in the ipo13b^ue57 mutants (n = 11 control and 8 ipo13b^ue57 animals). Scale bars: 500 nm (A, B), 100 nm (C, D). All data are presented as mean values ± SD. ***p < 0.001. Source data are provided as a Source Data file.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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