FIGURE

Fig 2

ID

ZDB-FIG-240215-113

Publication

Roehrig et al., 2024 - MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections

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Fig 2

MEndoB kills different staphylococcal species in various animal sera, at elevated temperatures, and remains stable upon storage for 4 h at 37°C in human serum. MEndoB activity in qKAs at 37°C against S. aureus ATCC 12600 (A) and S. epidermidis ATCC 35984 (B) in seven different animal sera and at 37°C, 40°C, and 42°C against S. aureus ATCC 12600 in human serum (C). Data shown in panel C for 37°C corresponds to data from Fig. 1B. Activity of MEndoB after incubation in human serum for 4 h at 37°C was determined in qKAs at 37°C against S. aureus ATCC 12600 (D). The limit of detection was 200 CFUs/mL (dotted line), and error bars indicate the standard error of the mean from two (A and B) and three (C and D) biological replicates.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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