FIGURE

Fig 3

ID

ZDB-FIG-240215-119

Publication

Roehrig et al., 2024 - MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections

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Fig 3

MEndoB effectively kills staphylococcal species in human whole blood. Time kill curves of different S. aureus and S. epidermidis strains in fresh human whole blood are shown. Human whole blood was inoculated with 10⁴ CFUs/mL S. aureus ATCC 12600 (MSSA) (A), S. aureus USA300 JE2 (MRSA) (B), S. epidermidis 1457 (MSSE) (C), or S. epidermidis ATCC 35984 (MRSE) (D) and MEndoB or PBS was added at three different concentrations [10, 50, and 100 nM for (A and B) and 40, 200, and 400 nM for (C and D)]. Bacterial survival was evaluated over time (5 min, 30 min, 1 h, 3 h, 6 h, and 24 h) (A–D). The limit of detection was 27 CFUs/mL (dotted line), and error bars show the standard error of the mean from four healthy donors. 100 nM = 4.6 µg/mL.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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