FIGURE

Fig 4

ID

ZDB-FIG-240215-120

Publication

Roehrig et al., 2024 - MEndoB, a chimeric lysin featuring a novel domain architecture and superior activity for the treatment of staphylococcal infections

Other Figures

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Fig 4

MEndoB rescues zebrafish larvae infected with S. aureus. Overview of the experimental procedure (A). Forty-eight-hour-old zebrafish larvae were injected with S. aureus Cowan I pCN56_GFPmut2 (2.5 × 10⁴ CFUs/fish) and treated with vehicle (PBS), vancomycin, or MEndoB 2 h post-infection. Survival of treated zebrafish larvae was monitored (n = 7) (B). Real-time GFP fluorescence images were overlayed with phase contrast microscopy images (C) and their intensity was quantified over time (D). Scale bar = 500 mm, scale bar of insets = 200 mm. Mean ± SD is shown (n = 7). ****P ≤ 0.0001, repeated measure two-way ANOVA.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB/TU
Condition:	bacterial treatment by injection: Staphylococcus aureus
Observed In:	whole organism
Stage:	Pec-fin

Phenotype Detail

Acknowledgments

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