FIGURE

Figure 6

ID

ZDB-FIG-231116-36

Publication

Taler et al., 2023 - Identification of Small Molecules for Prevention of Lens Epithelium-Derived Cataract Using Zebrafish

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Figure 6

Effects of 4-PBA treatment on TGFβ and EGFR signaling. (A–D) Confocal single-plane sections from eyes of plod3^vu222 mutants untreated (A,C) or treated with 4-PBA (B,D) from ~26 hpf. In (A,B), treatment was until ~96 hpf and sections were labeled for pSmad3 (red) and nuclei (Dapi, blue). In (C,D), treatment was until 76 hpf and sections were labeled for pERK1/2 (red) and nuclei (Dapi, blue). Asterisk in (A) marks the area of the cell mass where pSmad3 labeling is evident. Arrowheads in (B,D) point at the ALE. White line in (C) marks the periphery of the cell mass. L, lens. Scale bars are 20 µm.

Expression Data

Antibodies:	Ab2-smad3 Ab7-mapk
Fish:	plod3^vu222/vu222
Condition:	chemical treatment by environment: 4-phenylbutyric acid
Anatomical Term:	lens epithelium anterior side
Stage Range:	Protruding-mouth to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	plod3^vu222/vu222
Condition:	chemical treatment by environment: 4-phenylbutyric acid
Observed In:	lens epithelium
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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