FIGURE

Figure 5

ID

ZDB-FIG-231116-35

Publication

Taler et al., 2023 - Identification of Small Molecules for Prevention of Lens Epithelium-Derived Cataract Using Zebrafish

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Figure 5

TGFβ signaling is upstream of EGFR signaling in plod3 mutant lenses. (A,B) Timing experiments of rescue by TGFβ- and EGFR-signaling inhibition, respectively. Green bars show time windows with statistically significant rescue and red bars represent time windows in which no statistically significant rescue was observed. Numbers on bars are p-values. (C,D) Confocal single-plane sections from eyes of 76 hpf plod3^vu222 mutants treated with vehicle (C) or with SB-431542 (D) from ~26 hpf to 76 hpf and labeled for pERK1/2 (red) and nuclei (Dapi, blue). L, lens. Scale bar is 20 µm.

Expression Data

Antibody:	Ab7-mapk
Fish:	plod3^vu222/vu222
Condition:	chemical treatment by environment: SB 431542
Anatomical Term:	lens epithelium anterior side
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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