FIGURE

Figure 2

ID

ZDB-FIG-231116-33

Publication

Taler et al., 2023 - Identification of Small Molecules for Prevention of Lens Epithelium-Derived Cataract Using Zebrafish

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Figure 2

4-PBA inhibits development of lens cell masses in plod3 mutants: (A,C) Live 4 dpf plod3^vu222 mutant larvae, untreated (A) or treated with 4-PBA from 26 hpf (C). Arrows point at lenses. (B,D) Histological sections of eyes from 4 dpf plod3 mutant larvae, untreated (B) or treated with 4-PBA from 26 hpf (D). Arrow in (B) points at the abnormal cell mass and in (D) at the ALE that remains a monolayer. (E) Statistical analysis of the rescue with 4-PBA. Outside, normal and inside categories refer to the location of the lens relative to the normal location. N depicts the number of eyes analyzed. (F) Time windows of treatment with 4-PBA are represented by bars. Green bars show time windows with statistically significant rescue and red bar represents a time window in which no statistically significant rescue was observed. Numbers on bars are p-values. L, lens. Scale bars are 100 µm (A) or 20 µm (B).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	plod3^vu222/vu222
Condition:	chemical treatment by environment: 4-phenylbutyric acid
Observed In:	lens lens capsule lens epithelium
Stage:	Day 4

Phenotype Detail

Acknowledgments

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