FIGURE

Fig. 4

ID

ZDB-FIG-231020-58

Publication

Lai et al., 2023 - Xanthotoxin, a novel inducer of platelet formation, promotes thrombocytopoiesis via IL-1R1 and MEK/ERK signaling

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Fig. 4

XAT promotes megakaryopoiesis and thrombopoiesis in X-ray-induced thrombocytopenia mice. The effect of XAT on the changes in MPV(A) and PLT (B) in irradiated thrombocytopenia mice on days 1, 4, 7, 10, and 13. F _(5.289) = 5.983 (A); F _(5.228) = 38.26 (B); *P < .05, ^**P < .01, ^***P < .001, vs model; n = 10–12. ^###P < .001, vs control; n = 10–12. (C, D) The expression of CD41 + /CD61 + in BM cells. The histogram shows the proportions of CD41 + /CD61 + cells in each group. F _(5,15) = 6.764; *P < .05, ^**P < .01, ^***P < .001, vs model; n = 3^{. #}P < .05, vs control^; n = 3. (E, F) DNA ploidy changes in BM CD41 + cells. The histogram shows the percentage of DNA ploidy in CD41 + cells. F _(5.36) = 0.2684; *P < .05, ^**P < .01, ^***P < .001, vs model; n = 3. ^#P < .05, ^###P < .001, vs control; n = 3. (G, H) Representative figure of carotid artery thrombosis in each group after 13 days of treatment, and the histogram represents the mean carotid artery occlusion time in each group. F _(3,8) = 13.58; *P < .05, ^**P < .01, ^***P < .001, vs model; n = 3. ^##P < .01, vs control; n = 3. (I) The tail bleeding time of each group was detected after 13 days of treatment. F _(3.39) ⁼149.1; *P < .05, ^**P ^<.01, ^***P < .001, vs model; n = 3. ^###P ^<.001, vs control; n = 10–12.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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