FIGURE

Fig. 1

ID

ZDB-FIG-231020-55

Publication

Lai et al., 2023 - Xanthotoxin, a novel inducer of platelet formation, promotes thrombocytopoiesis via IL-1R1 and MEK/ERK signaling

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Fig. 1

XAT promotes Meg-01 cell differentiation. (A) The proliferation results of Meg-01 cells treated with 5, 10, 20 and 40 µM XAT. F _(4,93) = 17.06; *P < .05, ^**P < .01, ^***P < .001, vs control; n = 5–8. (B) LDH release results of Meg-01 cells treated with 5, 10 and 20 µM XAT. F ₍₃_,₁₀₉₎ = 4.770; *P < .05, ^**P < .01, ^***P < .001, vs control; n = 5–8. (C⁾ Representative images of Meg-01 cells treated with various concentrations of XAT (5, 10 and 20 µM) on the 4th and 6th days. The positive control is PMA (2.5 nM). (D) Count of MK-like cells in the field of view on the 4th (top) and 6th (bottom) days. F _(4,10) = 21.68 (top); F _(4,10) = 108.5 (bottom); *P < .05, ^**P < .01, ^***P < .001, vs control; n = 3. (E) The expression of CD41 + /CD42b+ in Meg-01 cells was measured on the 4th and 6th days after treatment with 5, 10, and 20 µM of XAT. The positive control was PMA (2.5 nM). (F) The percentage of CD41 + /CD42b+ cells on the 4th (left) and 6th (right) day. F _(4,10) = 10.87 (left); F _(4,10) = 35.97 (right);*P < .05, ^**P < .01, ^***P < .001, vs control; n = 3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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